The Steady-State Internal Redox State (NADH/NAD) Reflects the External Redox State and Is Correlated with Catabolic Adaptation in Escherichia coli
نویسندگان
چکیده
منابع مشابه
Redox State and Redox Environment in Biology
Cells and tissues must maintain a reducing environment to survive. This reducing environment provides the electrochemical gradient needed for electron flow. This movement of electrons provides the energy needed to build and maintain cellular structures and associated functions. An array of redox couples is responsible for the electron transfer. Some of these redox couples are linked to each oth...
متن کاملOverflow metabolism in Escherichia coli during steady-state growth: transcriptional regulation and effect of the redox ratio.
Overflow metabolism in the form of aerobic acetate excretion by Escherichia coli is an important physiological characteristic of this common industrial microorganism. Although acetate formation occurs under conditions of high glucose consumption, the genetic mechanisms that trigger this phenomenon are not clearly understood. We report on the role of the NADH/NAD ratio (redox ratio) in overflow ...
متن کاملLongest Path in Networks of Queues in the Steady-State
Due to the importance of longest path analysis in networks of queues, we develop an analytical method for computing the steady-state distribution function of longest path in acyclic networks of queues. We assume the network consists of a number of queuing systems and each one has either one or infinite servers. The distribution function of service time is assumed to be exponential or Erlang. Fu...
متن کاملProteostasis and REDOX state in the heart.
Force-generating contractile cells of the myocardium must achieve and maintain their primary function as an efficient mechanical pump over the life span of the organism. Because only half of the cardiomyocytes can be replaced during the entire human life span, the maintenance strategy elicited by cardiac cells relies on uninterrupted renewal of their components, including proteins whose special...
متن کاملThe tRNA thiolation pathway modulates the intracellular redox state in Escherichia coli.
We have performed a screening of hydroxyurea (HU)-sensitive mutants using a single-gene-deletion mutant collection in Escherichia coli K-12. HU inhibits ribonucleotide reductase (RNR), an enzyme that catalyzes the formation of deoxyribonucleotides. Unexpectedly, seven of the mutants lacked genes that are required for the incorporation of sulfur into a specific tRNA modification base, 5-methylam...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1999
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.181.8.2351-2357.1999